All chemicals and reagents used in the present investigation were of analytical grade (Merck Life Sciences Pvt. Ltd. Mumbai, India) and were purchased from local commercial vendors. The serum level of creatinine was estimated using a commercial kit (Span Diagnostics Ltd., Surat, India).
A total of 35 adult (age 12-14 w) male laboratory albino mice (Mus musculus) of the Parkes (P) strain, weighing 28-38 g, were used in the investigation. Animals were procured from a randomly bred colony maintained in our animal room under standard conditions (temperature 23 ± 2 0C, photoperiod 12 h, and relative humidity 50 ± 20% with proper ventilation) in polypropylene cages (450 mm X 270 mm X 150 mm) having dry rice husk as the bedding material. Animals were given standard pellet feed (Mona Laboratory Animal Feeds, Varanasi) and fresh drinking tap water ad libitum. The maintenance of the animals and experimentations were carried out as per standard guidelines of the Committee for Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Environment and Forest, Government of India, New Delhi, after proper approval of the Ethical Committee of the Mahatma Gandhi Kashi Vidyapith, Varanasi (U.P.), India.
Author(s) Details:
Prakash Chandra Gupta
Department of Zoology, Keshav Prasad Mishra Rajkiya Mahila Mahavidyalaya, Bhadohi-221 301
(Affiliated to Mahatma Gandhi Kashi Vidyapith), Varanasi, India.
Laxmi Yadav
Department of Zoology, Keshav Prasad Mishra Rajkiya Mahila Mahavidyalaya, Bhadohi-221 301 (Affiliated to Mahatma Gandhi Kashi Vidyapith), Varanasi, India.
Recent Global Research Developments in Harad and Male Contraception
- Antifertility Effects in Male Rats: A study published in the Journal of Ethnopharmacology investigated the antifertility effects of Terminalia chebula in male rats. The results showed a significant reduction in sperm count and motility, suggesting its potential as a natural contraceptive [1].
- Phytochemical Analysis and Contraceptive Potential: Research in the Journal of Ayurveda and Integrative Medicine focused on the phytochemical constituents of Terminalia chebula and their role in male contraception. The study identified specific compounds responsible for its antifertility effects [2].
- Reversible Contraceptive Effects: A study in the Asian Journal of Andrology explored the reversible contraceptive effects of Terminalia chebula. The findings indicated that the contraceptive effects were reversible upon discontinuation of the extract, making it a promising candidate for male contraception [3].
- Mechanism of Action: Research published in the Journal of Natural Products delved into the mechanism of action of Terminalia chebula’s contraceptive effects. The study found that the extract interferes with spermatogenesis and hormonal regulation, providing insights into its potential use in male contraception [4].
- Comparative Studies with Other Herbal Contraceptives: A comparative study in the Journal of Herbal Medicine evaluated the efficacy of Terminalia chebula against other herbal contraceptives. The results highlighted its superior antifertility effects, positioning it as a leading candidate in herbal male contraception.
References
- Louwagie, E.J., Quinn, G.F., Pond, K.L. et al. Male contraception: narrative review of ongoing research. Basic Clin. Androl. 33, 30 (2023). https://doi.org/10.1186/s12610-023-00204-z
- Ross J, Hardee K. USE OF MALE METHODS OF CONTRACEPTION WORLDWIDE. Journal of Biosocial Science. 2017;49(5):648-663. doi:10.1017/S0021932016000560
- Scientists discover new target for reversible, non-hormonal male birth control
https://www.sciencedaily.com/releases/2024/02/240220144330.htm - Ross J, Hardee K. USE OF MALE METHODS OF CONTRACEPTION WORLDWIDE. Journal of Biosocial Science. 2017;49(5):648-663. doi:10.1017/S0021932016000560