The aim of a recent study was to develop a dosage form of Ambroxol hydrochloride that could be easily administered to patients who have difficulty swallowing tablets or capsules. To achieve this, a complexation technique was used in combination with an ion-exchange resin called KYRON-T-114, which effectively masked the bitter taste of the drug. The drug loading onto the ion-exchange resin was optimized by evaluating various parameters such as the drug to resin ratio, pH, and soaking time. The resulting resinate was then characterized using FT-IR and DSC techniques to confirm the successful taste masking of the drug.
The taste-masked drug was then formulated into a fast-dissolving tablet (FDT) that was evaluated for various parameters such as hardness, friability, drug content, weight variation, content uniformity, water absorption ratio, in-vitro disintegration time, and in-vitro drug release studies. The data obtained from the FDT formulation was compared to that of a conventional marketed formulation and was found to be superior in terms of post-compression parameters such as weight variation, hardness, friability, wetting time, water absorption ratio, content uniformity, disintegration time, and dissolution.
The results of this study demonstrate that Ambroxol hydrochloride can be successfully taste-masked and formulated into an FDT as a suitable alternative to traditional tablets. This is particularly important for patients who have difficulty swallowing tablets or capsules, such as children or those with mental or physical challenges.
Author(s) Details:
Bimal Debbarma,
Institute of Pharmacy, Assam Don Bosco University, Tapesia, Assam-782402, India.
Please see the link here: https://stm.bookpi.org/ACPR-V4/article/view/12926
Keywords: Ambroxol hydrochloride, KYRON -T-114, taste masking, sodium starch glycolate, crospovidone