The viral family that includes the viruses linked to viral hemorrhagic fevers and the illnesses they cause is as follows: Family Arenaviridae: Hemorrhagic fever caused by the Chapare virus (CHPV). Venezuelan hemorrhagic fever is caused by the Guanarito virus (GTOV). Fever caused by the Argentine hemorrhagic virus (JUNV). Fever caused by the Lassa virus (LASV). Lujo hemorrhagic fever is caused by the Lujo virus (LUJV). The cause of lymphocytic choriomeningitis is the lymphocytic choriomeningitis virus (LCMV). The Machupo virus (MACV) causes hemorrhagic fever in Bolivia. Brazilian hemorrhagic fever is caused by the Sabia virus (SABV). The Bunyaviridae family includes the Crimean-Congo hemorrhagic fever virus (CCHFV). Dobrava-Belgrade virus (DOBV) – Renal syndrome accompanied by hemorrhagic fever. Hemorrhagic fever with renal syndrome is caused by the Hantaan virus (HTNV). Hemorrhagic fever with renal syndrome is caused by the Puumala virus (PUUV). Fever caused by the Rift Valley fever virus (RVFV). Hemorrhagic fever with renal syndrome is caused by the Saaremaa virus (SAAV). Severe fever with renal syndrome is caused by the Seoul virus (SEOV). SNV stands for Sin Nombre virus-Hantavirus pulmonary syndrome. The virus that causes severe fever and thrombocytopenia syndrome (SFTSV) is responsible for severe fever and thrombocytopenia syndrome. Hemorrhagic fever with renal syndrome caused by the Tula virus (TULV). The Ebola virus, or Bundibugyo Ebolavirus (BDBV), belongs to the Filoviridae family. Hemorrhagic fever is caused by the Marburg Marburgvirus (MARV). The Ebola virus disease is known as Sudan ebolavirus (SUDV). The Ebola virus disease is known as Tai Forest Ebolavirus (TAFV). Ebola virus disease: Zaire ebolavirus (EBOV). Family Flaviviridae: DENV-1-4, the dengue virus, causes dengue fever. Forest sickness caused by the Kyasanur Forest sickness Virus (KFDV). Omsk hemorrhagic fever is caused by the Omsk hemorrhagic fever virus (OHFV). Yellow fever virus, or YFV for short.
Author(s) Details:
Yash Srivastav
Azad Institute of Pharmacy & Research, Lucknow, U.P, India.
Mohd. Faijan Mansoori
Azad Institute of Pharmacy & Research, Lucknow, U.P, India.
Vipin Kumar Pandey
School of Pharmacy, Sangam University, Bhilwara, Rajasthan, India.
Recent Global Research Developments in Viral Hemorrhagic Fevers: An Overview
Pathogenesis and Therapeutics:
Hemorrhagic fever viruses (HFVs) pose a significant threat to global public health due to their emergence and re-emergence. VHFs caused by these viruses are characterized by acute febrile syndromes, coagulation abnormalities, and generalized hemorrhage, which can lead to life-threatening organ dysfunction.
The mechanisms underlying VHFs’ pathogenesis and the development of preventive and therapeutic options are still being explored. Researchers are investigating how these viruses cause multiorgan failure and exploring potential treatments [1].
Common Features and Virulence Mechanisms:
HFVs are highly infectious RNA viruses that can lead to viral hemorrhagic fever in humans. They often manifest as acute febrile syndromes with coagulation abnormalities and hemorrhage.
The frequency of hemorrhagic manifestations varies, but they represent a common sign of infection. HFVs are a major concern for global public health due to their potential as bioweapons and their ability to cause outbreaks with high fatality rates [1].
Therapeutics and Vaccines:
Ongoing research focuses on developing therapeutics and vaccines to treat VHFs. These efforts aim to mitigate the impact of these deadly diseases.
For more detailed information, you can refer to the comprehensive review published in the journal Frontiers in Microbiology [3].
References
- Flórez-Álvarez L, de Souza EE, Botosso VF, de Oliveira DBL, Ho PL, Taborda CP, Palmisano G, Capurro ML, Pinho JRR, Ferreira HL, Minoprio P, Arruda E, de Souza Ferreira LC, Wrenger C and Durigon EL (2022) Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential. Front. Microbiol. 13:1040093. doi: 10.3389/fmicb.2022.1040093