Whole genome sequencing has been used in several areas, including population genetics studies, genome-wide association studies (GWAS), clinical applications, and agricultural breeding programs. In biomedical research, whole-genome sequencing can be used in genome-wide association analyzes (GWAS) to find single nucleotide polymorphism (SNP) sites in the genome that are associated with specific diseases. In 2009, Illumina launched a whole-genome analysis kit for clinical medicine, which can be used by doctors when they do not know the cause of a patient’s disease and traditional treatments are ineffective. Whole genome sequencing of patients’ DNA is already helping physicians make treatment decisions. whole genome sequencing in diagnostics for rare diseases was recommended. The GWAS (genome-wide association study) technology based on whole-genome sequencing was used to identify rice agronomically important genes, and candidate genes were screened based on the estimated effects of nucleotide polymorphisms. Using this approach, Yano et al. identified four novel genes associated with agronomic traits.
Author(s) Details:
Hsiu-Lin Huang,
Department of Animal Science, National Chung Hsing University, 145 Xingda Road, Taichung 402, Taiwan.
I-Yen Huang,
Ugintech Co. Ltd., 5F-5, No. 282, Zhishi North 2nd Road, Taichung 407, Taiwan.
Chia-Yu Lin,
Johnson Chemical Pharmaceutical Works Co. Ltd., No. 77, Sec. 4, Sanhe Road, Sanchong Dist., New Taipei City 241, Taiwan.
Mu-Chiou Huang,
Department of Animal Science, National Chung Hsing University, 145 Xingda Road, Taichung 402, Taiwan.