The lack of correlation between Broder’s grades and the prognosis of OSCC has been explained by the fact that squamous cell carcinoma (SCC) usually exhibits a heterogenous cell population with difference in degree of differentiation. Broder’s system is limited and, in many instances, form insufficient basis for prognosis and therapy. Arthur and Farr, in a study of SCC of the mouth and pharynx, found that the histologic grade reflected the aggressiveness of the individual neoplasm and there was a clear relationship between grade and cure rate, stage of disease and metastatic involvement. McGavran et al. in a study of SCC of the larynx found a significant correlation between the frequency of metastasis and the type of invasive growth pattern.
Author(s) Details:
Varun Rastogi,
Department of Oral Pathology, UCMS, Bhairahawa, Nepal.
Nisha Maddheshiya,
Department of Oral Medicine & Radiology, IMS, Faculty of Dental Sciences, BHU, Varanasi, India.
Nitin Sangwan,
Department of Periodontology, UCMS, Bhairahawa, Nepal.