Male sex determination is mainly regulated by two testicular hormones. Testosterone, synthesized by the Leydig cells, maintains the wolffian duct. While AMH secreted by the immature Sertoli cells is responsible for the regression of mullerian mullerian ducts.
The PMDS involves patients with 46, XY karyotype and normal male external genitalia (usually associated with unilateral or bilateral cryptorchidism), in association with internal mullerian duct structures in variable locations (scrotal, inguinal and intraabdominal) depending on the location of testis, PMDS could be classified into three groups. The first group involves bilateral intra-abdominal testis in a position analogous to ovaries, which accounts for majority of the cases (60-70%). The second group (20-30%) involves one testis found in a hernial sac or scrotum in association with a contralateral inguinal hernia. The third group (10%) involves both testes located in the same hernia, together with fallopian tube and uterus.
Author(s) Details:
Roopak Aggarwal,
Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India.
Pinki Pandey,
Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India.
Anubhav Gautam,
Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India.
Sanjeev Kumar Singh,
Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India.
Md. Mubashir Ali Khan,
Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India.
Harender Kumar,
Sarojini Naidu Medical College, Agra, India.